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(Nasdaq: GUTS) (the Company or Fractyl), a clinical-stage metabolic therapeutics company focused on pioneering novel approaches to treat obesity and type 2 diabetes (T2D), today announced positive one-year results from its open-label REVEAL-1 Cohort

This pattern aligns with decades of diabetes research demonstrating that while rapid glycemic improvement carries short-term risks for retinopathy progression, sustained long-term glucose control reduces the incidence and severity of diabetic eye disease

In the Phase 2 trial, this approach resulted in net improvements in glycated hemoglobin and fasting glucose across all dose groups, confirming that the three receptors balance each other when introduced gradually

Glycated hemoglobin (HbA 1c ), systolic blood pressure and pulse rate were broadly similar between the CVOTs and glycemic efficacy trials